The role of antigen availability during B cell induction and its effect on sustained memory and antibody production after infection and vaccination-lessons learned from the SARS-CoV-2 pandemicArticle Published on 2022-12-312023-07-11 Journal: Clinical and experimental immunology [Category] COVID19(2023년), [키워드] antibodies antigens B cells memory vaccine. [DOI] 10.1093/cei/uxac113 PMC 바로가기
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humansArticle Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antibody Antigen antigenic breadth Breakthrough infection Cell comparable Delta develop dose Effect elicit Frequency Human increase increases in individual Infection memory memory B memory B cell memory B cells memory response Memory responses mRNA mRNA vaccine omicron plasma antibody receive response responses SARS-CoV-2 severe COVID-19 [DOI] 10.1084/jem.20221006 PMC 바로가기
A 1-year longitudinal study on COVID-19 convalescents reveals persistence of anti-SARS-CoV-2 humoral and cellular immunityCOVID-19 회복기에 대한 1년 종단 연구는 항 SARS-CoV-2 체액성 및 세포성 면역의 지속성을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 1-year after infection anti-SARS-CoV-2 humoral antibody antibody durability. caused CD4 CD8 CD8 T cell CD8 T cell responses Cell cellular immunity central memory circulating antibodies circulating antibody Cohort convalescent COVID-19 COVID-19 convalescent COVID-19 patient disease disease severity effective IgG level immune Immune components immune memory immune protection Immunity induce Infection information Kinetics maintain memory memory B memory B cell Memory responses memory T cells omicron Omicron variant peptide peptide pool persistence protective immunity provide RBD IgG Re-infection recorded response reveal SARS-CoV-2 SARS-CoV-2 circulating antibodies SARS-COV-2 infection subject Symptom T cell T cell response T cell responses T cells tested the RBD the SARS-CoV-2 variant [DOI] 10.1080/22221751.2022.2049984 PMC 바로가기 [Article Type] Article
What are the long-term holistic health consequences of COVID-19 among survivors? An umbrella systematic reviewArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute COVID-19 acute phase acute respiratory syndrome affected conducted consequence coronavirus COVID-19 COVID-19 treatments demographic data determine eligibility criteria employment Epidemiology fatigue functional Health Impact individual Laboratory parameters memory Pandemics Participants physical Psychological psychological impacts Quality of life ranged Research respiratory symptoms Sample SARS Coronavirus screened survived Survivors systematic review systematic reviews variant virus virus classification. [DOI] 10.1002/jmv.28086 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampusArticle Published on 2022-12-012022-11-16 Journal: Apoptosis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter Analysis Apoptosis assist Brain cause cells Central nervous system changes in Characteristics CNS COVID-19 degeneration demonstrated died distribution Effect glial cell glial cells granular hippocampus histological impairment increase in individual mechanisms memory microglia cells MONITOR Morphological morphological change morphology neurodegenerative disorder Neuroinflammation neurological Neuron neuronal neuronal cell organ oxidative stress recent reduce SARS-COV-2 infection Sholl analysis. the disease tissue sample virus while [DOI] 10.1007/s10495-022-01754-9 PMC 바로가기
Spike-specific T-cell responses in patients with COVID-19 successfully treated with neutralizing monoclonal antibodies against SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Administered analyzed CD4 CD8 cellular response Clinical outcome COVID-19 demonstrated effective evaluate Evolution flow cytometric group healthy controls immune memory Immunity Impact impair IMPROVE increases in individuals Infection initial investigated marker median memory memory T-cell response monoclonal antibodies monoclonal antibody neutralizing monoclonal antibody Patient patients patients treated patients with COVID-19 receiving SARS-CoV-2 significant increases in SOT spike statistically significant statistically significant difference T-cell Response T-cell response. treated Treatment Viral diseases were measured [DOI] 10.1016/j.ijid.2022.09.016 PMC 바로가기
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patientsArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Affect anti-CD20 anti-CD20 treatment antibody Antibody Response Antibody titers B cell B cells B-cell B-cell depletion Blood booster cellular response Cohort correlated detectable develop Efficacy Guidance humoral identify IgG^{+} interleukin-13 Logistic regression median memory multiple sclerosis naïve no correlation Odds ratio Patient patients predict predictor Probability recent rituximab S1 domain SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Seroconversion T-cell Response treated Treatment turn vaccination vaccination. vaccine responses [DOI] 10.1111/ene.15492 PMC 바로가기
CovidConvLSTM: A fuzzy ensemble model for COVID-19 detection from chest X-raysResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy activity affected applied chest X-ray Chest X-ray images CNN comparable ConvLSTM COVID-19 datasets deep learning ENhance experiments feature Features Fuzzy ensemble IMPROVE Local mechanism memory outbreak Pneumonia prevalent Research Spread Sugeno integral virus [DOI] 10.1016/j.eswa.2022.117812 [Article Type] Research article
DeepLPI: a novel deep learning-based model for protein-ligand interaction prediction for drug repurposingArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] 신약개발, [키워드] applied approved drug baseline CNN computational method COVID-19 dataset Davis downloaded drug-target interaction drugs Features high accuracy Interaction memory molecular patients predict protein-ligand interaction Research sequence target protein target protein sequence vector [DOI] 10.1038/s41598-022-23014-1 PMC 바로가기